At month 14, members missing on average 9
The majority of participants were black (68.6 per cent; 24.1 per cent white, 2.9 per cent Asian, 4.4 per cent multiracial/other) and female (86.1 per cent). Mean participant age was 46.1 ± 10.1 years, and mean BMI at baseline was 40.8 ± 5.9 kg/m 2 . 3 ± 2.9 per cent of initial weight (10.7 ± 4.0 kg). At week 52 of the weight loss maintenance RCT (i.e., 66 weeks total), lorcaserin-treated participants maintained an average loss of 7.8 ± 0.8 per cent of initial body weight (9.4 ± 0.9 kg), as measured from the start of the LCD program, compared with 6.6 ± 0.9 per cent (7.5 ± 1.0 kg) for those on placebo. As previously reported [ 18], lorcaserin-treated patients achieved a greater weight loss at week 24 of the RCT than participants who received placebo (11.7 vs. 8.4 per cent of initial body weight, p ?5 , SEb = 0.0001, p = .54; weight ? time 2 b = 3.35 ? 10 ?6 , SEb = 2.93 ? 10 ?6 , p = .25. (The effect of percent weight change on WBI, controlling for baseline BMI rather than height, was also tested and showed no significant effects.) Race did not significantly interact with WBIS scores or time. Overall, WBIS scores decreased by 0.40 points (SD = 0.92) from baseline to week 52 of the RCT (i.e., 66 weeks total): baseline M = 3.69 ± 1.14 (N = 133), week 14 M = 3.23 ± 1.21 (N = 137), week 24 of RCT M = 2.97 ± 1.26 (N = 105), and week 52 of RCT M = 3.23 ± 1.32 (N = 90).
In the event that communications ranging from race and you may WBIS try added to the fresh models, race moderated the relationship anywhere between standard WBIS and you will odds of achieving ? ten percent fat loss in the day 52 of your own RCT (we
Logistic regression show indicated that, at day twenty four of your own RCT, highest baseline WBIS scores forecast 37 % quicker odds of achieving ?5 per cent weight loss (p = .012) and 34 percent shorter likelihood of reaching ?ten percent dieting (p = .022; Dining table step one). That it perception wasn’t high within few days 52 to have weight loss regarding ?5 per cent (p = .48) otherwise ?ten percent (p = .13), neither for ?ten % weight-loss within few days fourteen (p = .22). age., 66 months overall; Otherwise = 2.twenty seven, 95% CI = 1.01, 5.09, p = .046). Certainly nonblack users, higher standard WBIS ratings was basically of the 62 per cent all the way down possibility (95% CI = 0.19, 0.80, p = .01) out-of gaining ?10 per cent dietary at the week 52, whereas zero effect of standard WBIS scores to your slimming down is actually found to have black participants (p = .94). Standard WBIS results failed to significantly relate to battle so you’re able to predict ?5 or ?10 % weight-loss at any most other big date part.
Bmi body mass index; Lcd reasonable-fat diet; RCT randomized managed demo. All the continued predictor details was basically depending during the their setting.
Body mass index bmi; Liquid crystal display lowest-calorie diet plan; RCT randomized managed trial. All the persisted predictor parameters was depending at their means.
The linear mixed model found no significant effect of baseline WBIS scores on rate of weight change at week 14 (b = ?0.002, SEb = 0.02, p = .91), or at week 24 (b = 0.03, SEb = 0.03, p = .23) or 52 (b = 0.002, SEb = 0.01, p = .90) of the RCT. Additionally, no significant interaction between race and WBI was found.